Human error is known to be the primary cause of quality and production losses in many industries. Although it is unlikely that human error will ever be eliminated, many human performance problems can be prevented. Human errors start at the design stage. Procedures play a vital role in human reliability. Nevertheless, it is essential to understand human behavior and the psychology of error as well as understand exactly where the instruction's weaknesses are so that procedures can be human engineered, improved and fixed.Areas Covered SOP writing outlineContent developmentThe rationale for procedure useRegulatory compliance backgroundUniversal purpose of proceduresThe Human PerspectiveHuman Error as a root causeThe thinking and reading processCommon mistakes and causesHow to create and maintain a procedureGoals of a procedureGood Procedure Writing practices (Terminology, Formats, layouts, mixed cases, steps content, familiar words, references, branching, conditional steps, the use of “Precautions”, “Warnings” and “Cautions,”Procedure stylesUse of electronic information networks for procedure accessWho Should AttendQA/QC directors and managersProcess improvement/excellence professionalsTraining leaders and managersPlant engineeringCompliance officersRegulatory professionalsExecutive managementManufacturing operations directorsHuman factors professionalsWhy Should AttendProcedures account for more than 40% of human error events in manufacturing. The majority of regulatory citations are also related to procedures. Procedures are essential for both execution and audits. These should be written for users without missing relevant information for regulators. Usually, procedures have weaknesses that harm productivity, quality, and regulatory standing. We will discuss from content development to formats designed for human error reduction due to procedures.